Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma
نویسندگان
چکیده
منابع مشابه
Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix.
Loss of genes at specific chromosomal loci is a common genetic alteration in human tumors and is thought to be critical for unmasking the recessive genetic changes for tumorigenesis. To learn whether such recessive mutations are involved in the development of carcinoma of the uterine cervix, 18 fresh tumors were analyzed by Southern blot hybridization using 34 polymorphic DNA markers covering 1...
متن کاملLoss of Heterozygosity on the Short Arm of Chromosome 3 in Carcinoma of the Uterine Cervix1
Loss of genes at specific chromosomal loci is a common genetic alteration in human tumors and is thought to be critical for unmasking the recessive genetic changes for tumorigenesis. To learn whether such recessive mutations are involved in the development of carcinoma of the uterine cervix, 18 fresh tumors were analyzed by Southern blot hybridi zation using 34 polymorphic DNA markers covering ...
متن کاملConsistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma.
Renal cell carcinoma (RCC) and normal kidney tissues have been examined from 34 patients with sporadic, nonhereditary RCC. Eighteen of the 21 cytogenetically examined tumors (86%) had a detectable anomaly of chromosome arm 3p distal to band 3p11.2-p13, manifested as a deletion, combined with the nonreciprocal translocation of a segment from another chromosome or monosomy 3. Restriction-fragment...
متن کاملLoss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma.
Malignant melanoma has been documented to display recurring abnormalities of chromosome 6, particularly the long arm (6q). Restriction fragment length polymorphism analysis was used as a molecular genetic approach to examine loci on chromosome 6q for loss of constitutional heterozygosity (LOH). Five DNA markers that recognize restriction fragment length polymorphisms along 6q and one polymorphi...
متن کاملLoss of heterozygosity (LOH) on chromosomes 2q, 3p and 21q in Indian oral squamous cell carcinoma.
Around the world, 200,000 people a year are affected by oral cancer, and the incidence of this disease is 10 times higher in India than Japan, mainly due to the custom of chewing tobacco. Loss of heterozygosity (LOH) on the long arm of chromosome 2 (2q), the short arm of chromosome 3 (3p) and the long arm of chromosome 21 (21q) are observed in several human cancers. We identified novel tumor su...
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ژورنال
عنوان ژورنال: Genes, Chromosomes and Cancer
سال: 1996
ISSN: 1045-2257,1098-2264
DOI: 10.1002/(sici)1098-2264(199610)17:2<118::aid-gcc7>3.3.co;2-m